Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells

FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-type or fALS (R521C) human FUS. Cell cultures were...

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Detalles Bibliográficos
Autores principales: Acosta, Jamie Rae, Goldsbury, Claire, Winnick, Claire, Badrock, Andrew P., Fraser, Stuart T., Laird, Angela S., Hall, Thomas E., Don, Emily K., Fifita, Jennifer A., Blair, Ian P., Nicholson, Garth A., Cole, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049593/
https://www.ncbi.nlm.nih.gov/pubmed/24912067
http://dx.doi.org/10.1371/journal.pone.0090572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049593/
https://www.ncbi.nlm.nih.gov/pubmed/24912067
http://dx.doi.org/10.1371/journal.pone.0090572

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