Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells

Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic lymphohistiocytosis type 4 (FHL-4), a disorder caused by mutations in the gene encoding the SNARE protein syntaxin 11. We show that syntaxin 11 binds to SNAP23 in NK cells and that this in...

Descripción completa

Detalles Bibliográficos
Autores principales: Hellewell, Andrew L., Foresti, Ombretta, Gover, Nicola, Porter, Morwenna Y., Hewitt, Eric W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049605/
https://www.ncbi.nlm.nih.gov/pubmed/24910990
http://dx.doi.org/10.1371/journal.pone.0098900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049605/
https://www.ncbi.nlm.nih.gov/pubmed/24910990
http://dx.doi.org/10.1371/journal.pone.0098900

Ejemplares similares