How and where are nonsense mRNAs degraded in mammalian cells?

The nonsense-mediated mRNA decay (NMD) pathway is responsible for the rapid degradation of eukaryotic mRNAs on which ribosomes fail to terminate translation properly. NMD thereby contributes to the elimination of aberrant mRNAs, improving the fidelity of gene expression, but also serves to regulate...

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Detalles Bibliográficos
Autores principales: Mühlemann, Oliver, Lykke-Andersen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2010
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049745/
https://www.ncbi.nlm.nih.gov/pubmed/20023408
http://dx.doi.org/10.4161/rna.7.1.10578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049745/
https://www.ncbi.nlm.nih.gov/pubmed/20023408
http://dx.doi.org/10.4161/rna.7.1.10578

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