Cargando…

O(6)-methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy

The O(6)-methylguanine-DNA methyltransferase (MGMT) protein protects cells from alkylating agents by removing alkyl groups from the O(6)-position of guanine. However, its effect on DNA damage induced by cyclophosphamide (CPM) is unclear. The present study investigated whether MGMT expression was cor...

Descripción completa

Detalles Bibliográficos
Autores principales:	ISONO, SAYURI, FUJISHIMA, MAKOTO, AZUMI, TATSUYA, HASHIMOTO, YUKIHIKO, KOMOIKE, YOSHIFUMI, YUKAWA, MASAO, WATATANI, MASAHIRO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049755/ https://www.ncbi.nlm.nih.gov/pubmed/24932232 http://dx.doi.org/10.3892/ol.2014.1985

Ejemplares similares

O(6)-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
por: Yu, Wei, et al.
Publicado: (2020)

O(6)-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms
por: Watanabe, Hirofumi, et al.
Publicado: (2020)

Induced Synthesis of O(6)‐Methylguanine‐DNA Methyltransferase in Rat Hepatoma Cells Exposed to DNA‐damaging Agents
por: Fukuhara, Masao, et al.
Publicado: (1992)

Management of Granulomatous Mastitis: A Series of 13 Patients Who Were Evaluated for Treatment Without Corticosteroids
por: Yukawa, Masao, et al.
Publicado: (2015)

O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
por: Egyházi, S., et al.
Publicado: (1995)

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.
por: Kokkinakis, D. M., et al.
Publicado: (1997)

O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
por: Altamura, Gennaro, et al.
Publicado: (2012)

Regulation of expression of O(6)-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)
por: CABRINI, GIULIO, et al.
Publicado: (2015)

O(6)‐Methylguanine‐DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives
por: Okamoto, Ryo, et al.
Publicado: (2002)

Determination of O(6)-Methylguanine in dried blood spot of breast cancer patients after cyclophosphamide administration()
por: Harahap, Yahdiana, et al.
Publicado: (2021)

Inhibition of O(6)-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli
por: Pearson, Steven J., et al.
Publicado: (2005)

Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival
por: Robinson, C G, et al.
Publicado: (2010)

Atomic Insight into the Altered O(6)-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer
por: Chikan, Naveed Anjum, et al.
Publicado: (2015)

O(6)-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
por: Fan, C-H, et al.
Publicado: (2013)

Prognostic value of O(6)-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas
por: Lam, Keng, et al.
Publicado: (2022)

Inactivation of O(6)-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers
por: Bae, S I, et al.
Publicado: (2002)

O(6)-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma
por: Ma, S, et al.
Publicado: (2003)

O(6)-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies
por: Sasai, Ken, et al.
Publicado: (2007)

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.
por: Middleton, M. R., et al.
Publicado: (1998)

O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer
por: Hasina, Rifat, et al.
Publicado: (2013)

O-6-methylguanine DNA methyltransferase is a favorable biomarker with proliferation suppressive potential in Breast Cancer
por: Lin, Danxia, et al.
Publicado: (2020)

Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics
por: Lasri, Ayoub, et al.
Publicado: (2020)

Autophagy deficiency downregulates O(6)methylguanine-DNA methyltransferase and increases chemosensitivity of liver cancer cells
por: Hou, Xiaojuan, et al.
Publicado: (2021)

Roles of the hydroxy group of tyrosine in crystal structures of Sulfurisphaera tokodaii O (6)-methylguanine-DNA methyltransferase
por: Kikuchi, Makiko, et al.
Publicado: (2021)

Erratum to: Prognostic value of O(6)-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas
Publicado: (2022)

Preferences for oral versus intravenous adjuvant chemotherapy among early breast cancer patients
por: Ishitobi, Makoto, et al.
Publicado: (2013)

Carcinosarcoma of the breast: A case of breast conservation surgery and breast reconstruction
por: Kanaizumi, Hirofumi, et al.
Publicado: (2019)

O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib
por: Watson, A J, et al.
Publicado: (2009)

Activity of irinotecan and temozolomide in the presence of O(6)-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models
por: Cai, W, et al.
Publicado: (2010)

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma
por: Jakob, Jens, et al.
Publicado: (2012)

O(6)-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents
por: Walter, T, et al.
Publicado: (2015)

High-dose radiotherapy in newly diagnosed low-grade gliomas with nonmethylated O(6)-methylguanine-DNA methyltransferase
por: Liu, Yanwei, et al.
Publicado: (2021)

The Impact of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine
por: Cannella, Lucia, et al.
Publicado: (2023)

Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement
por: Nagashima, Yukiko, et al.
Publicado: (2017)

Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
por: Wirtz, Stefan, et al.
Publicado: (2010)

The role of direct DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) in high grade malignant glioma
por: Manoj, M Jeru, et al.
Publicado: (2014)

Evaluation of O6-methylguanine-DNA methyltransferase enzyme expression effect on survival of patients with Grade 4 brain astrocytoma
por: Hemati, Simin, et al.
Publicado: (2014)

Immunohistochemical Assessment of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and Its Relationship with p53 Expression in Endometrial Cancers
por: Lee, Kyung Eun
Publicado: (2013)

In Silico Prediction of O(6)-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods
por: Sun, Guohui, et al.
Publicado: (2018)

O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications
por: Oliver, Jaime A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ohqe1vhm57jlgav9pci5o2evqp