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Pannexin-1 Is Blocked by Its C-Terminus through a Delocalized Non-Specific Interaction Surface

The Pannexin-1 (Panx1) channel is known to become activated under a variety of physiological conditions resulting in the release of medium-sized molecules such as ATP and amino acids from the cell. The detailed molecular mechanism of activation of the channel resulting in the opening of the Pannexin...

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Detalles Bibliográficos
Autores principales: Dourado, Michelle, Wong, Evera, Hackos, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049774/
https://www.ncbi.nlm.nih.gov/pubmed/24911976
http://dx.doi.org/10.1371/journal.pone.0099596