Fludarabine Downregulates Indoleamine 2,3-Dioxygenase in Tumors via a Proteasome-Mediated Degradation Mechanism

Indoleamine 2,3-dioxygenase (IDO) is found in multiple malignancies and exerts immunosuppressive effects that are central in protecting tumors from host T lymphocyte rejection. IDO is an enzyme involved in the catabolism of tryptophan resulting in inhibition of T lymphocyte function. While inhibitio...

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Detalles Bibliográficos
Autores principales: Hanafi, Laïla-Aïcha, Gauchat, Dominique, Godin-Ethier, Jessica, Possamaï, David, Duvignaud, Jean-Baptiste, Leclerc, Denis, Grandvaux, Nathalie, Lapointe, Réjean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050125/
https://www.ncbi.nlm.nih.gov/pubmed/24911872
http://dx.doi.org/10.1371/journal.pone.0099211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050125/
https://www.ncbi.nlm.nih.gov/pubmed/24911872
http://dx.doi.org/10.1371/journal.pone.0099211

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