Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Friesen, Claudia, Hormann, Inis, Roscher, Mareike, Fichtner, Iduna, Alt, Andreas, Hilger, Ralf, Debatin, Klaus-Michael, Miltner, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050161/
https://www.ncbi.nlm.nih.gov/pubmed/24626197
http://dx.doi.org/10.4161/cc.28493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050161/
https://www.ncbi.nlm.nih.gov/pubmed/24626197
http://dx.doi.org/10.4161/cc.28493

Ejemplares similares