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Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell pr...

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Detalles Bibliográficos
Autores principales:	Friesen, Claudia, Hormann, Inis, Roscher, Mareike, Fichtner, Iduna, Alt, Andreas, Hilger, Ralf, Debatin, Klaus-Michael, Miltner, Erich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050161/ https://www.ncbi.nlm.nih.gov/pubmed/24626197 http://dx.doi.org/10.4161/cc.28493

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