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EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains

Diacylglycerol kinase (DGK) α, which is activated by Ca(2+), contains a recoverin homology (RVH) domain, tandem repeats of two Ca(2+)-binding EF-hand motifs, two cysteine-rich C1 domains and the catalytic domain. We previously found that a DGKα mutant lacking the RVH domain and EF-hands was constitu...

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Detalles Bibliográficos
Autores principales: Yamamoto, Tatsuya, Sakai, Hiromichi, Sakane, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050180/
https://www.ncbi.nlm.nih.gov/pubmed/24918053
http://dx.doi.org/10.1016/j.fob.2014.04.003