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Chemical–genetic attenuation of focal neocortical seizures

Focal epilepsy is commonly pharmacoresistant, and resective surgery is often contraindicated by proximity to eloquent cortex. Many patients have no effective treatment options. Gene therapy allows cell-type specific inhibition of neuronal excitability, but on-demand seizure suppression has only been...

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Detalles Bibliográficos
Autores principales: Kätzel, Dennis, Nicholson, Elizabeth, Schorge, Stephanie, Walker, Matthew C., Kullmann, Dimitri M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050272/
https://www.ncbi.nlm.nih.gov/pubmed/24866701
http://dx.doi.org/10.1038/ncomms4847