Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors

ABSTRACT: 28 Derivatives of panaxadiol (PD) and panaxatriol were synthesized and evaluated for their anti-HBV activity on HepG 2.2.15 cells, of which 17 derivatives inhibited HBV DNA replication. Compounds 4, 9, 10, 14, and 15 showed moderate activity against HBV DNA replication with IC(50) values r...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Wang, Li-Jun, Ma, Yun-Bao, Huang, Xiao-Yan, Geng, Chang-An, Zhang, Xue-Mei, Chen, Ji-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050313/
https://www.ncbi.nlm.nih.gov/pubmed/24955298
http://dx.doi.org/10.1007/s13659-014-0018-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050313/
https://www.ncbi.nlm.nih.gov/pubmed/24955298
http://dx.doi.org/10.1007/s13659-014-0018-2

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