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Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of Hematopoiesis

Maintenance and differentiation of hematopoietic stem cells (HSCs) is regulated through cell-autonomous and non-cell-autonomous mechanisms within specialized bone marrow microenvironments. Recent evidence demonstrates that signaling by HIF-1α contributes to cell-autonomous regulation of HSC maintena...

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Detalles Bibliográficos
Autores principales: Guarnerio, Jlenia, Coltella, Nadia, Ala, Ugo, Tonon, Giovanni, Pandolfi, Pier Paolo, Bernardi, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050345/
https://www.ncbi.nlm.nih.gov/pubmed/24936467
http://dx.doi.org/10.1016/j.stemcr.2014.04.002