Biological conversion of aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug

N-acyloxyalkylation of NH-acidic compounds can be a prodrug approach for e.g. tertiary or some N-heterocyclic amines and secondary amides and have the potential to modify the properties of the parent drug for specific uses, for example its physicochemical, pharmacokinetic or biopharmaceutical proper...

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Detalles Bibliográficos
Autores principales: Rohde, Morten, M?rk, Niels, Håkansson, Anders E., Jensen, Klaus G., Pedersen, Henrik, Dige, Tina, J?rgensen, Erling B., Holm, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050360/
https://www.ncbi.nlm.nih.gov/pubmed/25756003
http://dx.doi.org/10.1016/j.rinphs.2014.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050360/
https://www.ncbi.nlm.nih.gov/pubmed/25756003
http://dx.doi.org/10.1016/j.rinphs.2014.04.002

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