In vivo siRNA delivery system for targeting to the liver by poly-l-glutamic acid-coated lipoplex()

In this study, we developed anionic polymer-coated liposome/siRNA complexes (lipoplexes) with chondroitin sulfate C (CS), poly-l-glutamic acid (PGA) and poly-aspartic acid (PAA) for siRNA delivery by intravenous injection, and evaluated the biodistribution and gene silencing effect in mice. The size...

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Detalles Bibliográficos
Autores principales: Hattori, Yoshiyuki, Nakamura, Ayako, Arai, Shohei, Nishigaki, Mayu, Ohkura, Hiroyuki, Kawano, Kumi, Maitani, Yoshie, Yonemochi, Etsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050376/
https://www.ncbi.nlm.nih.gov/pubmed/25756001
http://dx.doi.org/10.1016/j.rinphs.2014.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050376/
https://www.ncbi.nlm.nih.gov/pubmed/25756001
http://dx.doi.org/10.1016/j.rinphs.2014.01.001

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