SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency. Murine SIRT1 attenuates telomere attrition in vivo and is recruited at telomeres in induced pluripotent stem cells...

Descripción completa

Detalles Bibliográficos
Autores principales: De Bonis, Maria Luigia, Ortega, Sagrario, Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050480/
https://www.ncbi.nlm.nih.gov/pubmed/24936455
http://dx.doi.org/10.1016/j.stemcr.2014.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050480/
https://www.ncbi.nlm.nih.gov/pubmed/24936455
http://dx.doi.org/10.1016/j.stemcr.2014.03.002

Ejemplares similares