Cargando…

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency. Murine SIRT1 attenuates telomere attrition in vivo and is recruited at telomeres in induced pluripotent stem cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Bonis, Maria Luigia, Ortega, Sagrario, Blasco, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050480/ https://www.ncbi.nlm.nih.gov/pubmed/24936455 http://dx.doi.org/10.1016/j.stemcr.2014.03.002

Ejemplares similares

SIRT1 contributes to telomere maintenance and augments global homologous recombination
por: Palacios, Jose A., et al.
Publicado: (2010)

Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells
por: Marión, Rosa M., et al.
Publicado: (2011)

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
por: Agarwal, Suneet, et al.
Publicado: (2010)

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
por: McNees, Carolyn J., et al.
Publicado: (2010)

Zscan4 regulates telomere elongation and genomic stability in ES cells
por: Zalzman, Michal, et al.
Publicado: (2010)

Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination
por: Benetti, Roberta, et al.
Publicado: (2007)

Telomere elongation in parthenogenetic stem cells
por: Yin, Yu, et al.
Publicado: (2014)

A balance between elongation and trimming regulates telomere stability in stem cells
por: Rivera, Teresa, et al.
Publicado: (2016)

Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
por: Varela, Elisa, et al.
Publicado: (2016)

The mTOR pathway is necessary for survival of mice with short telomeres
por: Ferrara-Romeo, Iole, et al.
Publicado: (2020)

Telomere regulation in pluripotent stem cells
por: Huang, Yan, et al.
Publicado: (2014)

Survey of the necessary competencies and proficiency of safety officers in Thailand
por: ISHIMARU, Tomohiro, et al.
Publicado: (2020)

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes
por: de Silanes, Isabel López, et al.
Publicado: (2014)

Current understanding of genomic stability maintenancein pluripotent stem cells: Genomic stability maintenance in pluripotent stem cells
por: Zheng, Ping
Publicado: (2022)

Separating the effects of telomere size from the mechanism of telomere elongation
por: Lustig, Arthur J
Publicado: (2009)

The role of telomere-binding modulators in pluripotent stem cells
por: Li, Feng, et al.
Publicado: (2019)

Telomeres get SIRT-ified
por: Short, Ben
Publicado: (2010)

Identification of the Telomere elongation Mutation in Drosophila
por: Reddy, Hemakumar M., et al.
Publicado: (2022)

Stability of genomic imprinting in human induced pluripotent stem cells
por: Hiura, Hitoshi, et al.
Publicado: (2013)

A ‘higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs
por: Schoeftner, Stefan, et al.
Publicado: (2009)

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
por: Kimura, Masayuki, et al.
Publicado: (2008)

Zbtb34 promotes embryonic stem cell proliferation by elongating telomere length
por: Liu, Zheng, et al.
Publicado: (2022)

Telomere-driven diseases and telomere-targeting therapies
por: Martínez, Paula, et al.
Publicado: (2017)

Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells
por: Zhao, Shuang, et al.
Publicado: (2019)

Telomeres are elongated in rats exposed to moderate altitude
por: Wang, Yaping, et al.
Publicado: (2014)

BRD4 inhibitors block telomere elongation
por: Wang, Steven, et al.
Publicado: (2017)

Diversification and collapse of a telomere elongation mechanism
por: Saint-Leandre, Bastien, et al.
Publicado: (2019)

Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells
por: Luo, Lan, et al.
Publicado: (2014)

The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs
por: Liu, Qidong, et al.
Publicado: (2018)

Telomeres in cancer therapy
por: Blasco, María A
Publicado: (2001)

Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells
por: Fu, Haifeng, et al.
Publicado: (2018)

Role of Tet proteins in enhancer activity and telomere elongation
por: Lu, Falong, et al.
Publicado: (2014)

In situ visualization of telomere elongation patterns in human cells
por: Diolaiti, Morgan E., et al.
Publicado: (2013)

Telomere Elongation Frequently Observed during Tumor Metastasis
por: Takada, Toshinori, et al.
Publicado: (1992)

Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts
por: Parikh, Dhvani, et al.
Publicado: (2015)

ZSCAN4 Regulates Zygotic Genome Activation and Telomere Elongation in Porcine Parthenogenetic Embryos
por: Li, Xiao-Han, et al.
Publicado: (2023)

Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
por: Shimamoto, Akira, et al.
Publicado: (2015)

Telomeric RNAs are essential to maintain telomeres
por: Montero, Juan José, et al.
Publicado: (2016)

The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells
por: Chen, Yu, et al.
Publicado: (2020)

WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation
por: Gocha, April Renee Sandy, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hglbkkbpogrbm9il9f06sonfm7