Potential Novel Antibiotics from HTS Targeting the Virulence-regulating Transcription Factor, VirF, from Shigella flexneri

VirF is an AraC-type transcriptional regulator responsible for activating the transcription of virulence genes required for the intracellular invasion and cell-to-cell spread of Shigella flexneri. Gene disruption studies have validated VirF as a potential target for an anti-virulence therapy to trea...

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Detalles Bibliográficos
Autores principales: Emanuele, Anthony A., Adams, Nancy E., Chen, Yi-Chen, Maurelli, Anthony T., Garcia, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050983/
https://www.ncbi.nlm.nih.gov/pubmed/24549153
http://dx.doi.org/10.1038/ja.2014.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050983/
https://www.ncbi.nlm.nih.gov/pubmed/24549153
http://dx.doi.org/10.1038/ja.2014.10

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