Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss

BACKGROUND: Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation of Notch signaling in damaged mature cochleae, and have demonstrated the induc...

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Detalles Bibliográficos
Autores principales: Tona, Yosuke, Hamaguchi, Kiyomi, Ishikawa, Masaaki, Miyoshi, Takushi, Yamamoto, Norio, Yamahara, Kohei, Ito, Juichi, Nakagawa, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051152/
https://www.ncbi.nlm.nih.gov/pubmed/24884926
http://dx.doi.org/10.1186/1471-2202-15-66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051152/
https://www.ncbi.nlm.nih.gov/pubmed/24884926
http://dx.doi.org/10.1186/1471-2202-15-66

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