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Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
BACKGROUND: Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation of Notch signaling in damaged mature cochleae, and have demonstrated the induc...
Autores principales: | Tona, Yosuke, Hamaguchi, Kiyomi, Ishikawa, Masaaki, Miyoshi, Takushi, Yamamoto, Norio, Yamahara, Kohei, Ito, Juichi, Nakagawa, Takayuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051152/ https://www.ncbi.nlm.nih.gov/pubmed/24884926 http://dx.doi.org/10.1186/1471-2202-15-66 |
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