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The Challenge of Targeting Notch in Hematologic Malignancies
Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T-cell oncogene, with >50% of T-cell acute l...
Autores principales: | Hernandez Tejada, Fiorela N., Galvez Silva, Jorge R., Zweidler-McKay, Patrick A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051192/ https://www.ncbi.nlm.nih.gov/pubmed/24959528 http://dx.doi.org/10.3389/fped.2014.00054 |
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