Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

[Image: see text] Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of...

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Autores principales: Yin, Min, Yan, Yijun, Lohman, Jeremy R., Huang, Sheng-Xiong, Ma, Ming, Zhao, Guang-Rong, Xu, Li-Hua, Xiang, Wensheng, Shen, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051428/
https://www.ncbi.nlm.nih.gov/pubmed/24815182
http://dx.doi.org/10.1021/ol501179w
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author Yin, Min
Yan, Yijun
Lohman, Jeremy R.
Huang, Sheng-Xiong
Ma, Ming
Zhao, Guang-Rong
Xu, Li-Hua
Xiang, Wensheng
Shen, Ben
author_facet Yin, Min
Yan, Yijun
Lohman, Jeremy R.
Huang, Sheng-Xiong
Ma, Ming
Zhao, Guang-Rong
Xu, Li-Hua
Xiang, Wensheng
Shen, Ben
author_sort Yin, Min
collection PubMed
description [Image: see text] Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in natural product biosynthesis.
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spelling pubmed-40514282015-05-09 Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase Yin, Min Yan, Yijun Lohman, Jeremy R. Huang, Sheng-Xiong Ma, Ming Zhao, Guang-Rong Xu, Li-Hua Xiang, Wensheng Shen, Ben Org Lett [Image: see text] Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in natural product biosynthesis. American Chemical Society 2014-05-09 2014-06-06 /pmc/articles/PMC4051428/ /pubmed/24815182 http://dx.doi.org/10.1021/ol501179w Text en Copyright © 2014 American Chemical Society
spellingShingle Yin, Min
Yan, Yijun
Lohman, Jeremy R.
Huang, Sheng-Xiong
Ma, Ming
Zhao, Guang-Rong
Xu, Li-Hua
Xiang, Wensheng
Shen, Ben
Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title_full Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title_fullStr Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title_full_unstemmed Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title_short Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase
title_sort cycloheximide and actiphenol production in streptomyces sp. yim56141 governed by single biosynthetic machinery featuring an acyltransferase-less type i polyketide synthase
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051428/
https://www.ncbi.nlm.nih.gov/pubmed/24815182
http://dx.doi.org/10.1021/ol501179w
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