The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

Plasmodium falciparum serine hydroxymethyltransferase (PfSHMT), an enzyme in the dTMP synthesis cycle, is an antimalarial target because inhibition of its expression or function has been shown to be lethal to the parasite. As the wild-type enzyme could not be crystallized, protein engineering of res...

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Detalles Bibliográficos
Autores principales: Chitnumsub, Penchit, Ittarat, Wanwipa, Jaruwat, Aritsara, Noytanom, Krittikar, Amornwatcharapong, Watcharee, Pornthanakasem, Wichai, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051499/
https://www.ncbi.nlm.nih.gov/pubmed/24914963
http://dx.doi.org/10.1107/S1399004714005598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051499/
https://www.ncbi.nlm.nih.gov/pubmed/24914963
http://dx.doi.org/10.1107/S1399004714005598

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