A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination

Binding assays are increasingly used as a screening method for protein kinase inhibitors; however, as yet only a weak correlation with enzymatic activity-based assays has been demonstrated. We show that the correlation between the two types of assays can be improved using more precise screening cond...

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Detalles Bibliográficos
Autores principales: Rudolf, Amalie Frederikke, Skovgaard, Tine, Knapp, Stefan, Jensen, Lars Juhl, Berthelsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051630/
https://www.ncbi.nlm.nih.gov/pubmed/24915177
http://dx.doi.org/10.1371/journal.pone.0098800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051630/
https://www.ncbi.nlm.nih.gov/pubmed/24915177
http://dx.doi.org/10.1371/journal.pone.0098800

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