Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions

BACKGROUND: Insulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes. PERK (EIF2AK3) loss of function mutations in humans and mice exhibit permanent neonatal diabetes that...

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Detalles Bibliográficos
Autores principales: Wang, Rong, Munoz, Elyse E., Zhu, Siying, McGrath, Barbara C., Cavener, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051701/
https://www.ncbi.nlm.nih.gov/pubmed/24915520
http://dx.doi.org/10.1371/journal.pone.0099684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051701/
https://www.ncbi.nlm.nih.gov/pubmed/24915520
http://dx.doi.org/10.1371/journal.pone.0099684

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