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Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions
BACKGROUND: Insulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes. PERK (EIF2AK3) loss of function mutations in humans and mice exhibit permanent neonatal diabetes that...
Autores principales: | Wang, Rong, Munoz, Elyse E., Zhu, Siying, McGrath, Barbara C., Cavener, Douglas R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051701/ https://www.ncbi.nlm.nih.gov/pubmed/24915520 http://dx.doi.org/10.1371/journal.pone.0099684 |
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