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The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells
AIMS/HYPOTHESIS: We used the db/db mouse to determine the nature of the secretory defect in intact islets. METHODS: Glucose tolerance was compared in db/db and wild-type (WT) mice. Isolated islets were used: to measure insulin secretion and calcium in a two-photon assay of single-insulin-granule fus...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052007/ https://www.ncbi.nlm.nih.gov/pubmed/24705605 http://dx.doi.org/10.1007/s00125-014-3226-8 |