Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to produ...

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Detalles Bibliográficos
Autores principales: Zhang, Fang, Huang, Gang, Hu, Bo, Fang, Li-Ping, Cao, E-Hong, Xin, Xiao-Feng, Song, Yong, Shi, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052055/
https://www.ncbi.nlm.nih.gov/pubmed/24959003
http://dx.doi.org/10.1155/2014/257930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052055/
https://www.ncbi.nlm.nih.gov/pubmed/24959003
http://dx.doi.org/10.1155/2014/257930

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