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Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to produ...

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Detalles Bibliográficos
Autores principales:	Zhang, Fang, Huang, Gang, Hu, Bo, Fang, Li-Ping, Cao, E-Hong, Xin, Xiao-Feng, Song, Yong, Shi, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052055/ https://www.ncbi.nlm.nih.gov/pubmed/24959003 http://dx.doi.org/10.1155/2014/257930

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