Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC(50) value of 5 μM and without cytotoxic effects against J774.1 macrophages at 10...

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Detalles Bibliográficos
Autores principales: Oli, Swarna, Abdelmohsen, Usama Ramadan, Hentschel, Ute, Schirmeister, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052307/
https://www.ncbi.nlm.nih.gov/pubmed/24798927
http://dx.doi.org/10.3390/md12052614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052307/
https://www.ncbi.nlm.nih.gov/pubmed/24798927
http://dx.doi.org/10.3390/md12052614

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