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Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Fractionation

In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC(50) value of 5 μM and without cytotoxic effects against J774.1 macrophages at 10...

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Detalles Bibliográficos
Autores principales:	Oli, Swarna, Abdelmohsen, Usama Ramadan, Hentschel, Ute, Schirmeister, Tanja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052307/ https://www.ncbi.nlm.nih.gov/pubmed/24798927 http://dx.doi.org/10.3390/md12052614

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