Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells. It induced DNA damage and apoptosis in leukemia HL 60 cells. To fully underst...

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Detalles Bibliográficos
Autores principales: Shih, Huei-Chuan, El-Shazly, Mohamed, Juan, Yung-Shun, Chang, Chao-Yuan, Su, Jui-Hsin, Chen, Yu-Cheng, Shih, Shou-Ping, Chen, Huei-Mei, Wu, Yang-Chang, Lu, Mei-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052332/
https://www.ncbi.nlm.nih.gov/pubmed/24857964
http://dx.doi.org/10.3390/md12053072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052332/
https://www.ncbi.nlm.nih.gov/pubmed/24857964
http://dx.doi.org/10.3390/md12053072

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