An RNA Polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair

Histone modifications are major determinants of DNA double-strand break (DSB) response and repair. Here we elucidate a DSB repair function for transcription-coupled Set2 methylation at H3 lysine 36 (H3K36me). Cells devoid of Set2/H3K36me are hypersensitive to DNA-damaging agents and site-specific DS...

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Detalles Bibliográficos
Autores principales: Jha, Deepak Kumar, Strahl, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052371/
https://www.ncbi.nlm.nih.gov/pubmed/24910128
http://dx.doi.org/10.1038/ncomms4965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052371/
https://www.ncbi.nlm.nih.gov/pubmed/24910128
http://dx.doi.org/10.1038/ncomms4965

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