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An RNA Polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair
Histone modifications are major determinants of DNA double-strand break (DSB) response and repair. Here we elucidate a DSB repair function for transcription-coupled Set2 methylation at H3 lysine 36 (H3K36me). Cells devoid of Set2/H3K36me are hypersensitive to DNA-damaging agents and site-specific DS...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052371/ https://www.ncbi.nlm.nih.gov/pubmed/24910128 http://dx.doi.org/10.1038/ncomms4965 |