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‘Doubling down’ on the autophagy pathway to suppress tumor growth

In this issue of Genes & Development, Wei and colleagues (pp. 1204–1216) use elegant genetic approaches to simultaneously delete the essential autophagy gene FIP200 (FAK family-interacting protein of 200 kDa) and the signaling adaptor p62/SQSTM1 within established murine tumors, which reveals an...

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Detalles Bibliográficos
Autores principales: Leidal, Andrew M., Debnath, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052759/
https://www.ncbi.nlm.nih.gov/pubmed/24888584
http://dx.doi.org/10.1101/gad.244681.114