Cytotoxicity of Botulinum Neurotoxins Reveals a Direct Role of Syntaxin 1 and SNAP-25 in Neuron Survival

Botulinum neurotoxins (BoNT/A-G) are well-known to act by blocking synaptic vesicle exocytosis. Whether BoNTs disrupt additional neuronal functions has not been addressed. Here we report that cleavage of syntaxin 1 (Syx 1) by BoNT/C and cleavage of SNAP-25 by BoNT/E both induce degeneration of cultu...

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Detalles Bibliográficos
Autores principales: Peng, Lisheng, Liu, Huisheng, Ruan, Hongyu, Tepp, William H., Stoothoff, William H., Brown, Robert H., Johnson, Eric A., Yao, Wei-Dong, Zhang, Su-Chun, Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052923/
https://www.ncbi.nlm.nih.gov/pubmed/23403573
http://dx.doi.org/10.1038/ncomms2462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052923/
https://www.ncbi.nlm.nih.gov/pubmed/23403573
http://dx.doi.org/10.1038/ncomms2462

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