Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

INTRODUCTION: Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (mTORC1), which regulate cell-cycle progression an...

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Detalles Bibliográficos
Autores principales: Martin, Lesley-Ann, Pancholi, Sunil, Farmer, Ian, Guest, Stephanie, Ribas, Ricardo, Weigel, Marion T, Thornhill, Allan M, Ghazoui, Zara, A'Hern, Roger, Evans, Dean B, Lane, Heidi A, Johnston, Stephen R, Dowsett, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053110/
https://www.ncbi.nlm.nih.gov/pubmed/23075476
http://dx.doi.org/10.1186/bcr3330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053110/
https://www.ncbi.nlm.nih.gov/pubmed/23075476
http://dx.doi.org/10.1186/bcr3330

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