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All Your Base: a fast and accurate probabilistic approach to base calling

The accuracy of base calls produced by Illumina sequencers is adversely affected by several processes, with laser cross-talk and cluster phasing being prominent. We introduce an explicit statistical model of the sequencing process that generalizes current models of phasing and cross-talk and forms t...

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Detalles Bibliográficos
Autores principales: Massingham, Tim, Goldman, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053729/
https://www.ncbi.nlm.nih.gov/pubmed/22377270
http://dx.doi.org/10.1186/gb-2012-13-2-r13