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A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a structure-based framework, Coev2Net, for computing a single confidence score that add...

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Detalles Bibliográficos
Autores principales: Hosur, Raghavendra, Peng, Jian, Vinayagam, Arunachalam, Stelzl, Ulrich, Xu, Jinbo, Perrimon, Norbert, Bienkowska, Jadwiga, Berger, Bonnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053744/
https://www.ncbi.nlm.nih.gov/pubmed/22937800
http://dx.doi.org/10.1186/gb-2012-13-8-r76