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To be or not to be a piRNA: genomic origin and processing of piRNAs

Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.

Detalles Bibliográficos
Autores principales: Le Thomas, Adrien, Tóth, Katalin Fejes, Aravin, Alexei A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053809/
https://www.ncbi.nlm.nih.gov/pubmed/24467990
http://dx.doi.org/10.1186/gb4154