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To be or not to be a piRNA: genomic origin and processing of piRNAs
Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053809/ https://www.ncbi.nlm.nih.gov/pubmed/24467990 http://dx.doi.org/10.1186/gb4154 |
| _version_ | 1782320443895578624 |
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| author | Le Thomas, Adrien Tóth, Katalin Fejes Aravin, Alexei A |
| author_facet | Le Thomas, Adrien Tóth, Katalin Fejes Aravin, Alexei A |
| author_sort | Le Thomas, Adrien |
| collection | PubMed |
| description | Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate. |
| format | Online Article Text |
| id | pubmed-4053809 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40538092015-01-27 To be or not to be a piRNA: genomic origin and processing of piRNAs Le Thomas, Adrien Tóth, Katalin Fejes Aravin, Alexei A Genome Biol Review Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate. BioMed Central 2014 2014-01-27 /pmc/articles/PMC4053809/ /pubmed/24467990 http://dx.doi.org/10.1186/gb4154 Text en Copyright © 2014 Le Thomas et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Le Thomas, Adrien Tóth, Katalin Fejes Aravin, Alexei A To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title | To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title_full | To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title_fullStr | To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title_full_unstemmed | To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title_short | To be or not to be a piRNA: genomic origin and processing of piRNAs |
| title_sort | to be or not to be a pirna: genomic origin and processing of pirnas |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053809/ https://www.ncbi.nlm.nih.gov/pubmed/24467990 http://dx.doi.org/10.1186/gb4154 |
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