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5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation a...

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Detalles Bibliográficos
Autores principales: Klug, Maja, Schmidhofer, Sandra, Gebhard, Claudia, Andreesen, Reinhard, Rehli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053946/
https://www.ncbi.nlm.nih.gov/pubmed/23705593
http://dx.doi.org/10.1186/gb-2013-14-5-r46