Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines

We demonstrate a method for the prediction of chemotherapeutic response in patients using only before-treatment baseline tumor gene expression data. First, we fitted models for whole-genome gene expression against drug sensitivity in a large panel of cell lines, using a method that allows every gene...

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Detalles Bibliográficos
Autores principales: Geeleher, Paul, Cox, Nancy J, Huang, R Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054092/
https://www.ncbi.nlm.nih.gov/pubmed/24580837
http://dx.doi.org/10.1186/gb-2014-15-3-r47

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054092/
https://www.ncbi.nlm.nih.gov/pubmed/24580837
http://dx.doi.org/10.1186/gb-2014-15-3-r47

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