Measuring cell-type specific differential methylation in human brain tissue

The behavior of epigenetic mechanisms in the brain is obscured by tissue heterogeneity and disease-related histological changes. Not accounting for these confounders leads to biased results. We develop a statistical methodology that estimates and adjusts for celltype composition by decomposing neuro...

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Detalles Bibliográficos
Autores principales: Montaño, Carolina M, Irizarry, Rafael A, Kaufmann, Walter E, Talbot, Konrad, Gur, Raquel E, Feinberg, Andrew P, Taub, Margaret A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054676/
https://www.ncbi.nlm.nih.gov/pubmed/24000956
http://dx.doi.org/10.1186/gb-2013-14-8-r94

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054676/
https://www.ncbi.nlm.nih.gov/pubmed/24000956
http://dx.doi.org/10.1186/gb-2013-14-8-r94

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