THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data

Tumor samples are typically heterogeneous, containing admixture by normal, non-cancerous cells and one or more subpopulations of cancerous cells. Whole-genome sequencing of a tumor sample yields reads from this mixture, but does not directly reveal the cell of origin for each read. We introduce THet...

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Detalles Bibliográficos
Autores principales: Oesper, Layla, Mahmoody, Ahmad, Raphael, Benjamin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054893/
https://www.ncbi.nlm.nih.gov/pubmed/23895164
http://dx.doi.org/10.1186/gb-2013-14-7-r80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054893/
https://www.ncbi.nlm.nih.gov/pubmed/23895164
http://dx.doi.org/10.1186/gb-2013-14-7-r80

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