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THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data
Tumor samples are typically heterogeneous, containing admixture by normal, non-cancerous cells and one or more subpopulations of cancerous cells. Whole-genome sequencing of a tumor sample yields reads from this mixture, but does not directly reveal the cell of origin for each read. We introduce THet...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054893/ https://www.ncbi.nlm.nih.gov/pubmed/23895164 http://dx.doi.org/10.1186/gb-2013-14-7-r80 |