Performance on a pattern separation task by Alzheimer’s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels

INTRODUCTION: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer’s disease (AD). In mice, adult neurogenesis is reduced by knock-in alleles for human apolipoprotein E (ApoE) ∈4. Decreased dentate gyrus (DG) neural pr...

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Detalles Bibliográficos
Autores principales: Wesnes, Keith A, Annas, Peter, Basun, Hans, Edgar, Chris, Blennow, Kaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054957/
https://www.ncbi.nlm.nih.gov/pubmed/24735568
http://dx.doi.org/10.1186/alzrt250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054957/
https://www.ncbi.nlm.nih.gov/pubmed/24735568
http://dx.doi.org/10.1186/alzrt250

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