Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β(42) in neurons via regulation of cholesterol ester hydrolases

INTRODUCTION: The progressive dementia that is characteristic of Alzheimer’s disease is associated with the accumulation of amyloid-beta (Aβ) peptides in extracellular plaques and within neurons. Aβ peptides are targeted to cholesterol-rich membrane micro-domains called lipid rafts. Observations tha...

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Detalles Bibliográficos
Autores principales: Simmons, Charlotte, Ingham, Victoria, Williams, Alun, Bate, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055000/
https://www.ncbi.nlm.nih.gov/pubmed/24625058
http://dx.doi.org/10.1186/alzrt245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055000/
https://www.ncbi.nlm.nih.gov/pubmed/24625058
http://dx.doi.org/10.1186/alzrt245

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