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Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β(42) in neurons via regulation of cholesterol ester hydrolases

INTRODUCTION: The progressive dementia that is characteristic of Alzheimer’s disease is associated with the accumulation of amyloid-beta (Aβ) peptides in extracellular plaques and within neurons. Aβ peptides are targeted to cholesterol-rich membrane micro-domains called lipid rafts. Observations tha...

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Detalles Bibliográficos
Autores principales:	Simmons, Charlotte, Ingham, Victoria, Williams, Alun, Bate, Clive
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055000/ https://www.ncbi.nlm.nih.gov/pubmed/24625058 http://dx.doi.org/10.1186/alzrt245

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