MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

The chromatin template imposes an epigenetic barrier during the process of somatic cell reprogramming. Here, using fibroblasts derived from macroH2A double knockout mice we show that these histone variants act cooperatively as a barrier to induced pluripotency. Through manipulation of macroH2A isofo...

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Detalles Bibliográficos
Autores principales: Gaspar-Maia, Alexandre, Qadeer, Zulekha A., Hasson, Dan, Ratnakumar, Kajan, Leu, N. Adrian, Leroy, Gary, Liu, Shichong, Costanzi, Carl, Valle-Garcia, David, Schaniel, Christoph, Lemischka, Ihor, Garcia, Benjamin, Pehrson, John R., Bernstein, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055026/
https://www.ncbi.nlm.nih.gov/pubmed/23463008
http://dx.doi.org/10.1038/ncomms2582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055026/
https://www.ncbi.nlm.nih.gov/pubmed/23463008
http://dx.doi.org/10.1038/ncomms2582

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