Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

INTRODUCTION: Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer’s disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term effic...

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Detalles Bibliográficos
Autores principales: Blurton-Jones, Mathew, Spencer, Brian, Michael, Sara, Castello, Nicholas A, Agazaryan, Andranik A, Davis, Joy L, Müller, Franz-Josef, Loring, Jeanne F, Masliah, Eliezer, LaFerla, Frank M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055090/
https://www.ncbi.nlm.nih.gov/pubmed/25022790
http://dx.doi.org/10.1186/scrt440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055090/
https://www.ncbi.nlm.nih.gov/pubmed/25022790
http://dx.doi.org/10.1186/scrt440

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